鼠疫疫苗的研究现状和进展

刘丽,汪巨峰,李波*

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (11) : 945-948.

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中国药学杂志 ›› 2013, Vol. 48 ›› Issue (11) : 945-948. DOI: 10.11669/cpj.2013.12.001
综述

鼠疫疫苗的研究现状和进展

  • 刘丽1,汪巨峰1,李波2*
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文章历史 +

摘要

目的对鼠疫疫苗的研究进展进行综述,为新型鼠疫疫苗的研究和应用提供参考。方法通过查阅近年来与鼠疫疫苗有效性和安全性研究相关的国内外文献,进行归纳总结。结果与结论现有鼠疫疫苗因其在保护力和安全性方面的限制,需要开发更为安全有效的新型鼠疫疫苗。鼠疫亚单位疫苗、DNA疫苗和应用新佐剂及改变接种途径的鼠疫疫苗等是目前和今后一段时间内的研究热点。对鼠疫菌候选抗原的研究是鼠疫亚单位疫苗研究的基础。新型鼠疫疫苗对增加使用者依从性、提高疫苗免疫效果和安全性具有重要意义。

关键词

鼠疫疫苗 / 灭活疫苗 / 减毒活疫苗 / 鼠疫亚单位疫苗 / DNA疫苗 / 鼠疫菌候选抗原 / F1抗原 / V抗原

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刘丽,汪巨峰,李波*. 鼠疫疫苗的研究现状和进展[J]. 中国药学杂志, 2013, 48(11): 945-948 https://doi.org/10.11669/cpj.2013.12.001
中图分类号: R965   

参考文献

[1] HANG’OMBE B M, NAKAMURA I, SAMUI K L, et al. Evidence of Yersinia pestis DNA from fleas in an endemic plague area of Zambia . BMC Res Notes,2012, 5(1): 72.

[2] COBBS C G, CHANSOLME D H. Plague . Dermatol Clin, 2004, 22(3): 303-312.

[3] ROLLINS S E, ROLLINS S M, RYAN E T. Yersinia pestis and the plague . Am J Clin Pathol, 2003, 119: 78-85.

[4] BEVINS S N, BAROCH J A, NOLTE D L, et al. Yersinia pestis: Examining wildlife plague surveillance in China and the USA . Integr Zool, 2012, 7(1): 99-109.

[5] LAZARUS A A, DECKER C F. Plague . Respir Care Clin N Am, 2004, 10(1): 83-98.

[6] WANG J Y, WEI D, WANG G Z. Research progress in plague vaccine . Prog in Microbiol Immunol(微生物学免疫学进展), 2011, 39(2): 60-64.

[7] QUENEE L E,CORNELIUS C A,CILETTI N A, et al. Yersinia pestis caf1 variants and the limits of plague vaccine protection . Infect Immun, 2008, 76(5): 2025-2036.

[8] CUI P. Research progress in plague vaccine . Progress in Veterinary Medicine(动物医学进展), 2009, 30(5): 84 -86.

[9] TITBALL R W, WILLIAMSON E D. Yersinia pestis (plague) vaccines . Expert Opin Biol Ther, 2004, 4(6): 965-973.

SUN W, ROLAND K L, CURTISS R 3rd. Developing live vaccines against plague . J Infect Dev Ctries, 2011, 5(9): 614-627.

QUENEE L E, SCHNEEWIND O. Plague vaccines and the molecular basis of immunity against Yersinia pestis . Hum Vaccin, 2009, 5(12):817-823.

CAO L,LIM T,JUN S,et al. Vulnerabilities in Yersinia pestis caf operon are unveiled by a Salmonella vector . PLoS One, 2012, 7(4):36283.

GROSFELD H, COHEN S, BINO T, et al. Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen . Infect Immun, 2003, 71: 374-383.

DU Y, ROSQVIST R, FORSBERG A. Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis . Infect Immun, 2002, 70(3): 1453-1460.

LI B, DU C, ZHOU L, et al. Humoral and cellular immune responses to Yersinia pestis infection in long-term recovered plague patients . Clin Vaccine Immunol, 2012, 19(2):228-234.

ODHI A,SHARMA R K,BATRA H V. Yersinia rLcrV and rYopB inhibits the activation of murine peritoneal macrophages vitro E . Immunol Lett, 2005, 99(2): 146 -152.

SUN W, CURTISS R 3rd. Amino acid substitutions in LcrV at putative sites of interaction with Toll-like receptor 2 do not affect the virulence of Yersinia pestis . Microb Pathog, 2012, 53(5-6):198-206.

OVERHEIM K A, DEPAOLO R W, DEBORD K L, et al. LcrV plague vaccine with altered immunomodulatory properties . Infect Immun, 2005, 73(8): 5152-5159.

JIANG L X, YANG R F, YU S Y. Research on plague vaccine . Chin J Endemiol(中国地方病学杂志), 2004, 23 (3): 285 -287.

JIAO L, WANG B X. Current status and prospects of research on new plague vaccines . Int J Biol(国际生物制品学杂志), 2011, 34 (4): 200-203.

BENNER G E, ANDREWS G P, RUSSEL W, et al. Immune response to Yersinia outer proteins and other Yersinia pestis antigens after experimental plague infection in mice . Infect Immun, 1999, 67: 1922-1928.

SUOMALAINEN M, HAIKO J, RAMU P, et al. Using every trick in the book: The Pla surface protease of Yersinia pestis . Adv Exp Med Biol, 2007, 603: 268-278.

FEODOROVA V A, DEVDARIANI Z L. Development, characterization and diagnostic application of monoclonal antibodies against Yersinia pestis fibrinolysin and coagulase . Med Microbiol, 2000, 49: 261-269.

VALLS SER N M, HAIKO J, D E GROOT P G, et al. Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis . J Thromb Haemost, 2010, 8(10): 2232-2240.

SEBBANE F, JARRETT C O, GARDER D, et al. Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague . Proc Natl Acad Sci, 2006, 103(14): 5526-5530.

SIMON S, DEMEURE C, LAMOURETTE P, et al. Fast and simple detection of yersinia pestis applicable to field investigation of plague foci . PLoS One, 2013, 8(1):4947.

VERNATI G, EDWARDS W H, ROCKE T E, et al. Antigenic profiling of Yersinia pestis infection in the Wyoming coyote (Canis latrans) . J Wildl Dis, 2011, 47(1): 21-29.

WANG S, JOSHI S, MBOUDJEKA I, et al. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice . Vaccine, 2008, 26(13): 1664-1674.

ZHANG Q W, QI Z Z, XIN Y Q, et al. Evaluation of immunization protection efficacy of plague subunit vaccine . Chin J Prev Med(中华预防医学杂志), 2009, 43(9):785-788.

FU L F, HAO Z Z, CHANG Y L, et al. Titer test for serum antibody in mice immunized by the plague subunit vaccine and potency testing of plague vaccine in guinea pigs . Int J Biol(国际生物制品学杂志), 2010, 33 (1): 1-5.

QUENEE L E, CILETTI N, BERUBE B, et al. Plague in Guinea pigs and its prevention by subunit vaccines . Am J Pathol, 2011, 178(4):1689-1700.

QI Z, ZHOU L, ZHANG Q, et al. Comparison of mouse, guinea pig and rabbit models for evaluation of plague subunit vaccine F1+rV270. Vaccine, 2010, 28(6): 1655-1660.

WILLIAMSON E D, PACKER P J, WATERS E L, et al. Recombinant (F1+V) vaccine protects cynomolgus macaques against pneumonic plague . Vaccine, 2011, 29(29-30): 4771-4777.

POWELL B S, ANDREWS G P, ENAMA J T, et al. Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plague . Biotechnol Prog, 2005, 21(5): 1490-1510.

DEL P G, SANTI L. Andrianaivoarimanana V Plant-derived recombinant F1,V,and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system . Int J Immunopathol Pharmacol, 2009, 22(1): 133 -143.

RIGANO M M, MANNA C, GIULINI A. Plants as bio-factories for the production of subunit vaccines against bio-security-related bacteria and viruses . Vaccine, 2009, 27: 3463-3466.

ELVIN S J, EYLES J E, HOWARD K A, et al. Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine . Vaccine, 2006, 24(20): 4433-4439.

FEODOROVA V A, CORBEL M J. Prospects for new plague vaccines . Expert Rev Vaccines, 2009, 8(12): 1721-1738.

YAMANAKA H, HOYT T, YANG X, et al. A parenteral DNA vaccine protects against pneumonic plague . Vaccine, 2010, 28(18):3219-3230.

WANG S, MBOUDJEKA I, GOGUEN J D. Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines . Vaccine, 2010, 28(8): 2011-2019.

WANG S, HEILMAN D, LIU F, et al. A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague . Vaccine, 2004, 22: 3348-3357.

AMEMIYA K, MEYERS J L, ROGERS T E, et al. CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague . Vaccine, 2009, 27(16): 2220-2229.

基金

国家“重大新药创制”科技重大专项资助项目(2012ZX09302001,2012ZX09505001-004)

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